CD8A and renal cell carcinoma: We found that with the onset of RCC can Plasma Blast-Plasma Cell expression levels (OR = 0.96, 95%CI = 0.92–1.00, P = 3.65 × 10–2), and the same trend was observed in the MR-Egger method (OR = 0.90, 95%CI = 0.85–0.96, P = 4.78 × 10–3).The expression level of HVEM on Effector Memory CD8 + T cell was also found to be increased (OR = 0.94, 95%CI = 0.88–1.00, P = 4.37 × 10–2).