Meanwhile, the estimation of the occurrence of RCC for CD8 + T cells was 1.04 (95%CI = 1.00–1.08, P = 2.83 × 10–2), with the same trend, although the other methods were not statistically significant (Table 2, Fig. 3).Effector Memory CD4 + T cells (OR = 1.04, 95% CI = 1.00–1.08, P = 4.51 × 10–2) and Effector Memory CD8 + T cell (OR = 1.04, 95%CI = 1.00–1.08, P = 4.51 × 10–2) also observed a similar trend (Supplementary Table 7). This evidence concerns the gene CD4 and renal cell carcinoma.