Experiments in mice (Chen et al. 2010; Hernández-Porras et al. 2014; Inoue et al. 2014) and fish (Runtuwene et al. 2011; Bonetti et al. 2014a; Solman et al. 2022; Anastasaki et al. 2012) suggest the efficacy of inhibiting the RAS/MAPK signal via MEK inhibitors (MEKi) administration in preventing RASopathy-associated developmental defects. The gene discussed is MAP2K7; the disease is RASopathy.