In our study, we first identified some parameters related to low muscle mass among elderly Chinese participants with T2DM and found that participants with low muscle mass a had significantly lower BMI, BF, ASMI, HOMA-β,ALT,AST, FPCP and PPCP concentrations (P < 0.0001 for PPCP; P < 0.05 for ALT,AST and FPCP; P < 0.001 for BMI, BF, ASMI, and HOMA-β;). The gene discussed is GPT; the disease is type 2 diabetes mellitus.