In contrast, cancer cells in a mesenchymal state exhibit reduced cell-to-cell contacts and acquire mesenchymal properties, making them more susceptible to ferroptosis [47].Secondly, the loss of cell–cell adhesion increases the vulnerability of cells to lipid peroxidation, leading to ferroptosis [48], it has been observed that overexpressed enzymes such as ACSLs and SCD1, which are involved in lipid metabolism and increased unsaturation index, induce EMT and increase the migration/invasion of colorectal cancer cells [49]. The gene discussed is SCD; the disease is colorectal cancer.