Yeast NDI1 is well expressed in MPP+/MPTP-induced PD cell culture and mouse models, and it can effectively compensate for the functional defects of mitochondrial complex I, thereby reducing the MPTP-induced injury of dopaminergic neurons in SNpc of mice, with substantial improvements in neuropathologic and neurobehavioral manifestations. This evidence concerns the gene AVPR2 and Parkinson disease.