It is interesting to note that the overexpression of ten genes (AIMP2, AURKA, AURKB, CDC45, CDCA3, CKS1B, HMGB3, KPNA2, MCM5, and NCAPD2) and the low expression of three genes (NUPR1, and SLC1A3) were associated with poor prognosis in melanoma. The gene discussed is CDCA3; the disease is melanoma.