The R/RCC DEPs were associated with activated hepatic fibrosis signaling pathway, activated pulmonary fibrosis idiopathic signaling pathway, activated role of osteoblasts in rheumatoid arthritis signaling pathway, activated pathogen induced cytokine storm signaling pathway, activated glioma signaling, activated molecular mechanisms of cancer, activated axonal guidance signaling, activated inhibition of matrix metalloproteases, activated WNT/β-catenin signaling, activated tumour microenvironment pathway and activated HIF1-α signaling. This evidence concerns the gene HIF1A and central nervous system cancer.