The R/P DEPs were associated with activated intrinsic prothrombin activation pathway, activated GP6 signaling pathway, inhibited thrombin signaling, inhibited natural killer cell signaling, inhibited IL-8 signaling, inhibited systemic lupus erythematosus in B cell signaling pathway, inhibited B cell receptor signaling and inhibited Huntington’s disease signaling. Here, F2 is linked to juvenile Huntington disease.