Similarly, SHM7/MSA1, which regulates S-adenosylmethionine (SAM) production and DNA methylation including the methylation of S-deficiency responsive genes, such as the main sulfate transporters SULTR1;1 and SULTR1;2 [40], was included in cluster 8 (Fig. 3B). This evidence concerns the gene COQ2 and hyperinsulinemic hypoglycemia, familial, 4.