In the Vk∗MYC Vk12653 tumor-bearing mice (Fig. 2I), transferrin and iron levels remarkably decreased in serum of peripheral blood (Fig. 2J, K), but both dramatically accumulated in the bone marrow-derived CD138+B220− cells (Fig. 2L, M) from day 21 to day 42. The gene discussed is SDC1; the disease is neoplasm.