In contrast, among individuals without prior infection, specific CD4 T cell levels towards spike of the parental SARS-CoV-2 or of the Omicron subvariants BA.1, BA.2 or BA.4/5 correlated with IgG titers, and neutralizing activity towards the parental SARS-CoV-2, and BA.5, and in part towards BA.1 or BA.2 variants, whereas specific CD8 T cells did not show any correlation with humoral immunity (Fig. 4b). Here, CD8A is linked to infection.