Anterior uveitis alone or with posterior segment involvement including vitritis, cystoid macular edema, sub-retinal fluid, serous retinal detachment or papillitis have been reported secondary to immune checkpoint inhibitor cytotoxic T-Lymphocyte antigen (CTLA-4) and anti PD-1 therapy, each separate or in combination anti-CTLA-4/anti-PD-1 therapy [150–153]. This evidence concerns the gene CTLA4 and cystoid macular edema.