Our results showed that ACOX1 and CPT2 were significantly downregulated in colorectal cancer tissues compared with normal tissues, as shown in Fig. 11A. Finally, we compared the expression levels of ACOX1 and CPT2 in normal intestinal epithelial cells and four CRC cell lines by PCR assay and found that the expression levels of ACOX1 and CPT2 genes were significantly down-regulated in tumor cells (Fig. 11B). The gene discussed is ACOX1; the disease is colorectal cancer.