HFE and esophageal disorder: Three nonsynonymous index variants for manganese (rs13107325 [SLC39A8], rs1800562 [HFE], rs855791 [TMPRSS6]) and one index variant for cadmium in high LD with nonsynonymous SNPs (rs953733 [DUOX2]) were associated with phecodes (Supplementary Data 7, Fig. 1): The manganese decreasing variant in the metal ion transporter gene SLC39A8 (rs13107325) was positively associated with diseases of the esophagus and with musculoskeletal conditions.