IDH2 and acute myeloid leukemia: We then obtained the third TF list by applying NetAct15, which identifies the enriched TFs by performing gene set enrichment analysis (GSEA, with slight adjustments15) using a curated TF-target database on the differentially expressed genes (defined as those with the adjusted p-values below 0.05 by using limma26) between the normal controls and the AML patients with IDH mutations (Fig. 2c).