From single KD perturbations, the top five destabilizers of the AML state are TFDP1, E2F4, TP53, MYC, and E2F1; in contrast, the top five destabilizers of the normal state are STAT3, RB1, POU2F1, ETS2, and MYCN, as shown in Supplementary Fig. 3. The gene discussed is E2F4; the disease is acute myeloid leukemia.