From single KD perturbations, the top five destabilizers of the AML state are TFDP1, E2F4, TP53, MYC, and E2F1; in contrast, the top five destabilizers of the normal state are STAT3, RB1, POU2F1, ETS2, and MYCN, as shown in Supplementary Fig. 3. This evidence concerns the gene MYC and acute myeloid leukemia.