Intriguingly, we found an increased FOXP3+ T cell abundance in anti-CTLA4 resistant tumor lesions and there are reports describing that the immunosuppressive properties of FOXP3+ T cells are dependent on TCR signaling53 suggesting that the increased TCR clonality reflects an increased immunosuppressive environment mediated by FOXP3+ T regulatory cells. The gene discussed is FOXP3; the disease is neoplasm.