Patients with MDS-SFB31 harbored distinct mutation patterns with higher frequencies of DNMT3A mutations (17% vs. 5%, P = 0.004) and TET2 mutations (34% vs. 12%, P < 0.001) compared to those with MDS, NOS with SLD and MLD (Supplementary Table 4a). The gene discussed is DNMT3A; the disease is myelodysplastic syndrome.