Sun et al. discovered that human USC-derived exosomes (USC-Exo) carry long non-coding RNA (lncRNA) TUG1, which regulates Acyl-CoA synthetase long-chain family member 4 (ACSL4) -mediated ferroptosis through interaction with SRSF1, thereby protecting against renal IRI-induced AKI [6]. The gene discussed is ACSL4; the disease is acute kidney injury.