ITGAM and cancer: Studies suggests that high salt conditions in culture media prompt the specific differentiation of peripheral blood mononuclear cells toward an M2 macrophage phenotype (CD11b+CD14lowCD16 + ), indicating that high salt environments, similar to those observed in tumor microenvironments, drive the accumulation of anti-inflammatory M2 macrophages, negatively correlated with cancer prognosis [173, 175].