Pathologically, FTD is characterized by abnormal accumulations of TAR DNA binding protein (TARDBP), hyperphosphorylated tau or FET proteins, which encompass EWS RNA binding protein 1 (EWSR1), TATA-box binding protein associated factor 15 (TAF15) and FUS RNA binding protein (FUS)159. This evidence concerns the gene TAF15 and frontotemporal dementia.