Further supporting a pathogenic role for immune effectors in the progression of DLB, CD4+ (but not CD8+) T cells have been shown to infiltrate the brain parenchyma of patients with DLB and SNCA-expressing mice, a rodent model of the disease that also manifests intracranial accumulation of natural killer T (NKT) cells154, a small lymphoid cell population with potent reactive traits155,156. Here, CD4 is linked to Lewy body dementia.