However, other studies showed lower sensitivity for the TS-EIA (52%)25 and the Vircell Syphilis ELISA IgG+IgM (73.2%)30 and for the specificity of the ICE Syphilis detection pack (61.5%), Enzywell TP (59%),32 and Vircell Syphilis ELISA IgG+IgM (62.6%).34 The gene discussed is CD40LG; the disease is syphilis.