In the present study, we demonstrated that the changed release pattern of DAMPs in MCP‐deficient pancreatic cancer cells was essential for the polarization of tumoricidal‐polarized pro‐inflammatory macrophages, and that there was upregulation of CD80, CD86, and inducible nitric oxide synthase (iNOS) were up‐regulated in this cohort of macrophages. Here, CD80 is linked to familial pancreatic carcinoma.