PF4 and familial pancreatic carcinoma: In our in vitro, in vivo, and PDO‐based experiments, the tumors tended to stimulate the polarization of macrophages toward the pro‐resolution M2‐like type, as cancer cells can produce numerous products, including extracellular matrix components, interleukin‐10, colony‐stimulating factor‐1, and chemokines such as CCL2, CCL18, CCL17, and CXCL4.[52, 53, 54, 55] Stimulation of ferroptosis with RSL3 in pancreatic cancer cells did not alter pro‐resolution M2‐like macrophage polarization.