Consistent with our in vitro findings (Supplementary Fig. S1H), baseline PPIA mRNA levels in the KRASG12X xenograft models surveyed above (NSCLC, PDAC, colorectal cancer, GAC, and OVCA) demonstrated minimal variation and no association with RMC-6236 response (Supplementary Fig. S3G and Supplementary Table S4). This evidence concerns the gene PPIA and non-small cell lung carcinoma.