Cellular pERK inhibition data from representative cancer cell lines harboring different RAS mutant alleles treated with RMC-6236 (Supplementary Fig. S1D) were also in general agreement with the biochemical data, with KRASG12V mutant cell lines being most sensitive, notwithstanding the potential impact of other factors in a human cancer cell line that can influence apparent potency for inhibition of signaling. The gene discussed is EIF2AK3; the disease is cancer.