No significant association was found between RMC-6236 tumor volume response and the presence of functional alterations in genes reflecting major comutation classes and associated with disease etiology in each indication (oncoplots in Fig. 3A–C), albeit we noted a (nonsignificant) trend in the occurrence of oncogenic mutations in KEAP1 and SMARCA4 as well as loss of expression of CDKN2A in KRASG12X NSCLC models with somewhat reduced responses (Fig. 3A). Here, KEAP1 is linked to non-small cell lung carcinoma.