The amyloid cascade hypothesis posits that AD pathogenesis is caused by the accumulation of Aβ in the brain, triggering a cascade of inflammation, tau accumulation and the generation of neurofibrillary tangles, synaptic dysfunction, and subsequent neuronal death (Hardy & Allsop, 1991; Mattsson‐Carlgren et al., 2021; Therriault et al., 2021). This evidence concerns the gene MAPT and Alzheimer disease.