MAPT and Alzheimer disease: Borrelia burgdorferi, which is associated with Lyme disease (Miklossy, 2011), has also been hypothesised to play a role in AD pathogenesis as it has been found to colocalise with plaques in AD patients, and its in vitro infection of mammalian cells induced an increase in the levels of Aβ and phosphorylated tau (Senejani et al., 2022).