Among them, HLH possessed 3 protective alleles [i.e., B*15:02 (OR: 0.43; 95% CI: 0.26–0.72), Pc = 0.02; C*08:01 (OR: 0.61; 95% CI: 0.45–0.83, Pc = 0.02); and DQB1*03:01 (OR: 0.74; 95% CI: 0.62–0.89, Pc = 0.04)] and 2 risk alleles [i.e., A*01:01 (OR: 2.04; 95% CI: 1.50–2.76, Pc = 0.02) and DRB1*10:01 (OR: 2.54; 95% CI: 1.76–3.66, Pc = 0.02)]. Here, HLA-DRB1 is linked to hemophagocytic syndrome.