Jacquerie et al. [27] reported an evident increase in several critical growth factors, including matrix metalloproteinases and chemokines (IGFBP-1, TGF-β, IL-8, YKL-40, and MMP-7) in induced sputum of scleroderma patients with pulmonary involvement, thus proposing sputum as a suitable and minimally invasive fluid to predict and monitor the evolution of the disease and treatment response. This evidence concerns the gene CHI3L1 and scleroderma.