RHD and anemia (phenotype): Although immunoprophylaxis with the use of anti-Rh immunoglobulin has significantly reduced the emergence of new cases of maternal immunization, Rh alloimmunization still exists in developing and developed countries, and without a doubt, this is the pathology responsible for the vast majority of fetuses with moderate to severe anemia, requiring IUT therapy as the only treatment to prevent the death of the fetus [17].