Phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB; also known as AKT), and mechanistic target of rapamycin kinase (mTOR) have been suggested as common signals mediating the development of neurodegenerative diseases such as SCZ, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and the development of cancer including lung, breast, colorectal, and prostate (Vanderplow et al. 2021; Sanaei et al. 2022). The gene discussed is MTOR; the disease is early-onset autosomal dominant Alzheimer disease.