The tumor volume (day 21: WT, 110.83 ± 12.96; TNFR2 KO, 68.96 ± 5.99 mm3, day 28: WT, 126.42 ± 15.93; TNFR2 KO, 76.08 ± 10.77 mm3, Fig. 2A) and weight (WT, 44.60 ± 14.77 mg; TNFR2 KO, 15.44 ± 9.40 mg, Fig. 2B) in TNFR2 KO mice were significantly lowered compared with the WT mice. This evidence concerns the gene TNFRSF1B and neoplasm.