In tumorigenesis, TNFR plays important roles in multiple aspects of tumor progression, including the proliferation of cancer cells, the evasion of immune surveillance, the activation of endothelial cells and angiogenesis, and the formation of a pre-metastasis milieu (Sheng et al. 2018; Atretkhany et al. 2020). Here, TNFRSF1A is linked to neoplasm.