BMI indicates Body Mass index; HFrEF, Heart Failure reduced Ejection Franction; HFpEF, Heart Failure preserved Ejection Fraction; COPD, chronic obstructive pulmonary disease; CKD, chronic kidney disease; ACEIs, Angiotensine Converting enzyme Inhibitors; ARBs, Angiotensin Receptor Blockers; SAPS2, Simplified Acute Physiology Score; pts, patients; ICU, Intensive Care Unit, SOFA, Sepsis-Related Organ Failure Assessment; PEEP, Positive End Expiratory Pressure; FiO2, Fraction of Inspired Oxygen; pts, patients. The gene discussed is ACE; the disease is heart failure.