Across Prosigna risk groups, a significant difference in distribution of grade (p < 0.001), PR status (p = 0.011), Ki67 status (p < 0.001), tumor size (p = 0.001) and intrinsic subtype (p < 0.001) was observed (Table 4) and Ki67 status, tumor size, lymph node status and intrinsic subtype all remained significant among grade 2 cases (Supplementary Table S5). Here, MKI67 is linked to neoplasm.