In cancers, including MM, inflammatory and hypoxic conditions lead to overexpression of the adenosine production machinery, such as CD39 and CD73 (ecto-5′-nucleotidase) in tumor cells, CAFs, Tregs, and MDSCs, which consequently results in an excessive accumulation of extracellular adenosine (32, 33). The gene discussed is NT5E; the disease is neoplasm.