We also demonstrate that the relative number of CD163-positive (CD163+) M2 macrophages in chrysotile-induced MMs is considerably greater than in crocidolite-induced tumors, suggesting that chrysotile induces a more profound immunosuppressive tumor microenvironment that creates favorable conditions for tumors to evade immune surveillance in Bap1+/− mice. The gene discussed is CD163; the disease is neoplasm.