Moreover, in the entire 100 NCI human MM RNA-seq dataset (16), CD163 mRNA expression showed a highly significant positive correlation with multiple genes encoding proteins involved in the CD39/CD73–adenosine, CCR2, and other immunosuppressive pathways, that is, IL10, IL10RA, MRC1 (CD206), and STAT3 (Fig. 7C), forming an interconnected network consistent with our mouse data. This evidence concerns the gene STAT3 and Miyoshi myopathy.