Moreover, in the entire 100 NCI human MM RNA-seq dataset (16), CD163 mRNA expression showed a highly significant positive correlation with multiple genes encoding proteins involved in the CD39/CD73–adenosine, CCR2, and other immunosuppressive pathways, that is, IL10, IL10RA, MRC1 (CD206), and STAT3 (Fig. 7C), forming an interconnected network consistent with our mouse data. Here, IL10 is linked to Miyoshi myopathy.