IL6, one of the major players in asbestos-induced chronic inflammation implicated in MM (29), can cooperate synergistically with Ccl2/Ccr2 signaling to alter the TIME toward immunosuppression by attracting myeloid-derived suppressor cells (MDSC), M2 macrophages, and regulatory T cells (Treg) as well as activating associated factors (19). Here, CCR2 is linked to Miyoshi myopathy.