In a subsequent meta-analysis by the same group, PVT patients free from cirrhosis exhibit significantly higher prevalence of the factor V Leiden (FVL) mutation (OR, 1.85; 95% CI, 1.09–3.13) or the prothrombin G20210A mutation (OR, 5.01; 95% CI, 3.03–8.30) [24]. The gene discussed is F2; the disease is Cirrhosis.