Another recent meta-analysis was performed on the prevalence of acquired and hereditary thrombophilia among Indian patients with non-cirrhotic PVT [25], thus showing PC deficiency in 10.7%, Janus kinase 2 (JAK-2) mutation in 8.5%, and antiphospholipid antibodies (APLA) in 7.5% [25]. The gene discussed is JAK2; the disease is pyruvate carboxylase deficiency disease.