Patients with CKD had higher in-hospital mortality compared to the NKF group (64.0 vs. 18.8%, p < 0.001), but the CKD group had other co-existing chronic diseases like diabetes (44.0 vs. 20.3%, p = 0.008), coronary artery disease (48.0 vs. 11.4%, p < 0.001), older age (75.5 ± 12.6 vs. 64.0 ± 15.9 [y], p = 0.001), and a higher concentration of NT-proBNP (23,378.6 ± 32,018.2 vs. 8720.2 ± 16,937.2 [ng/dL], p = 0.032) than the NKF group. This evidence concerns the gene NPPB and chronic kidney disease.