Selective depletion of Nrp2 on endothelial cells (Nrp1/2flflPDGFb.iCreER) inhibited primary tumor growth, as well as metastasis and secondary site angiogenesis by inducing the rapid transport and degradation of VEGFR2 to Rab7+ endosomes [119]. This evidence concerns the gene NRP2 and neoplasm.