Within malignant pleural effusions (MPEs), pleural fluid containing cancer and immune cells secondary to metastasis, macrophages which expressed high levels of Nrp2 had significantly increased Tie2 (pro-angiogenic), IRF5 and CD86 (pro-inflammatory), PD-L1 (immunosuppressive), and CX3CR1 (tissue homing) [46]. This evidence concerns the gene CD274 and cancer.