Genetic depletion of either Nrp2a or Nrp2b in macrophages in vitro inhibited phagocytosis/endosomal processing of apoptotic tumor cells, increased tumor cell migration in response to culture with Nrp2aKO/Nrp2bKO macrophage supernatants, and decreased IL-10 production in response to LPS [46]. This evidence concerns the gene IL10 and neoplasm.