The diagnosis is made when there is an absolute increase in the blood concentrations of cardiac troponins, cTn, and high-sensitivity cT (hs-cTnT and hs-cTnI), above the 99th percentile associated with typical symptoms of myocardial ischemia and pathognomonic changes in instrumental examinations [28]. Here, TNNI3 is linked to myocardial ischemia.