CNR1 and Anxiety: In addition to acting on cannabinoid CB1/CB2 receptors, CBD may reduce pain through its interaction with the putative non-CB1/CB2 cannabinoid G protein-coupled receptor (GPCR) 55 or GPCR 18 (GPR18), also known as the N-arachidonoyl glycine (NAGly) receptor, and other well-known GPCRs, such as opioid or serotonin (5-HT) receptors, which contribute to the effectiveness of low-dose CBD for reducing stress, anxiety, and pain.