Values of NT-proBNP, BNP, and mid-regional pro-atrial natriuretic peptide (MR-proANP) lower than125 pg/mL (or ng/L), 35 pg/mL, and <40 pmol/L, respectively, have been considered to be highly reliable in ruling out HF (negative predictive value of 95–99%) [8]. The gene discussed is NPPB; the disease is hydrops fetalis.