We also found an upregulation of key activating receptors on γδ T-cells expanded after exercise, and antibody blocking of NKG2D abrogated the augmented cytotoxic effects of exercise against a multiple myeloma (U266) but not a chronic myeloid leukemia (K562) cell line (10). Here, KLRK1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.