Interestingly, recent work has shown that pre-tangle pathology (with an antibody that detects phosphorylated Tau at S422) coincided with the loss of staining of the p75 neurotrophic factor receptor (NTR) in the basal forebrain of patients with no cognitive impairment (NCI) or mild cognitive impairment (MCI); furthermore, these changes correlated with cognitive decline and AD neuropathology, confirming earlier studies that showed a connection between BFCN cell loss and Tau pathology [102]. This evidence concerns the gene NTSR1 and Cognitive impairment.