Preliminary studies using spatial transcriptomics on paraffin embedded blocks suggest that there is an overexpression of Dyrk1A in specific hippocampal layers in postmortem human tissue (personal communication, Granholm) that is correlated with Tau-related alterations in the DS-AD brain, suggesting a definite link between p-Tau and Dyrk1A. The gene discussed is MAPT; the disease is Alzheimer disease.