A French study conducted on 100 patients that received TIPS between 2011 and 2016, following a complete cardiac evaluation, tried to identify the predictive factors of post-TIPS heart failure: increased QTc values, aortic stenosis, diastolic dysfunction, left atrial dilatation, and increased pre-TIPS brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) values [49]. The gene discussed is NPPB; the disease is aortic stenosis.