Risk factors for the development of steroid-induced OHT and SIG are as follows: individual susceptibility, likely related to different isoforms of the glucocorticoids receptors; older and younger age, especially children younger than 6 years; glaucomatous patients and first-degree relatives of glaucomatous patients; connective tissue diseases; and high myopia, DM type I [74]. Here, NR3C1 is linked to connective tissue disorder.