LEP and obesity due to melanocortin 4 receptor deficiency: The previously mentioned aspects are also connected with obesity/overweight frameworks, in which an active pro-inflammatory state is characterized by higher levels of pro-inflammatory cytokines, alterations in the homeostasis of the adipocytokines-leptin system, adiponectin related to hyperinsulinemic states, modification of energy metabolism, and mitochondrial oxidative stress [4].