Although it has been proposed that some FHA women with PCOM initially had simple PCOS before [4,15,27,28] and that they reveal a hyper-responsiveness of LH to a GnRH bolus similar to PCOS patients [27], the data suggest that in both groups, the demise in GnRH pulsatility was comparable. This evidence concerns the gene GNRH1 and polycystic ovary syndrome.