Using a mouse model, Sadighi Akha et al.140 demonstrated that IL-22 and CD160, a protein anchored to the surface of intestinal intraepithelial lymphocytes, are involved in the phosphorylation of signal transducer and activator of transcription 3 (STAT3) in the context of CDI. The gene discussed is IL22; the disease is clostridium difficile infection.