By applying the SMR method (Zhu et al., 2016), we found that the higher expression of RSPO3 (ENSG00000146374) in adipose subcutaneous would be associated with increased the risk of type 2 diabetes (OR = 1.102, 95%CI = 1.031–1.179, p=0.004), but decreased the risk of fracture (OR = 0.695, 95%CI = 0.566–0.854, p=0.0005) (Figure 4C and Supplementary file 1h). The gene discussed is RSPO3; the disease is type 2 diabetes mellitus.