PRDM12 and hereditary sensory and autonomic neuropathy: There was no evidence of reduced pain sensation elsewhere on the body, with no reports of lip, tongue, inner cheek or corneal injuries, or deficiencies in sweating or lacrimation, as would be expected in any form of CIP, including PRDM12-CIP.6 Particularly noteworthy is the lack of severe and deep facial (and elsewhere) Staphylococcus aureus infections, despite the constant itching and skin injuries; repeated significant S. aureus infections are an obligatory feature of Mendelian disorders of congenital nociceptor deficiency, including PRDM12-CIP/HSAN8.6