PRDM12 and hereditary sensory and autonomic neuropathy: In 2015, PRDM12 mutations were linked to congenital insensitivity to pain (CIP), resembling hereditary autonomic and sensory neuropathy types 4 and 5 (HSAN4 and HSAN5) and designated PRDM12-CIP or HSAN8 (Table S1; see Supporting Information).6,7 In all three conditions, the normal embryonic development of nociceptive sensory neurons fails.7,8 Most PRDM12-CIP variants are stop, splicing or null missense mutations.