The accumulation of histone H1 in the cytosol has been observed in mouse models of prion and Alzheimer's diseases (Bolton & Betmouni, 1999) and in response to the CDK inhibitor flavopiridol in primary chronic lymphoid leukemia cells (Harshman et al., 2013). The gene discussed is H1-0; the disease is early-onset autosomal dominant Alzheimer disease.