The MCODE analysis generated 37 hub genes, including ALB, TNF, IL6, VEGFA, IGF1, HIF1A, FOS, CRP, IL10, MMP2, CD34, IGF2, SOX9, POMC, TGFB1, AR, HGF, IFNG, LOX, VWF, ZEB1, AFP, PRL, ELN, GCG, BRCA1, CREBBP, MUC1, PDGFB, SLC2A4, SST, CD40LG, TFRC, IGFBP1, AMH, CD38, COL2A1 that participated in the HIF-1, PI3K-Akt, MAPK, AGE-RAGE signaling pathway in diabetic complications. The gene discussed is AKT1; the disease is diabetes mellitus.