The IVW method indicates that genetically-predicted POMC (OR [95%]=0.716 [0.5287 to 0.9717], p = 0.0319) and VWF (OR [95%]=0.9988 [0.9976 to 0.9999], p = 0.0363) possess a clear protective effect on unilateral inguinal hernia. The gene discussed is VWF; the disease is Inguinal hernia.