The MCODE analysis generated 37 hub genes, including ALB, TNF, IL6, VEGFA, IGF1, HIF1A, FOS, CRP, IL10, MMP2, CD34, IGF2, SOX9, POMC, TGFB1, AR, HGF, IFNG, LOX, VWF, ZEB1, AFP, PRL, ELN, GCG, BRCA1, CREBBP, MUC1, PDGFB, SLC2A4, SST, CD40LG, TFRC, IGFBP1, AMH, CD38, COL2A1 that participated in the HIF-1, PI3K-Akt, MAPK, AGE-RAGE signaling pathway in diabetic complications. This evidence concerns the gene RENBP and diabetes mellitus.