Moreover, treatment of HCC cells with Z-VAD-FMK, a cell-permeable and irreversible pan-caspase inhibitor, also suppressed the CFZ-induced apoptosis (Supplementary Figure S1B) as well as the activation of caspase-3 and PARP (Figure 6G,H), which further demonstrated that CFZ induced apoptosis in HCC cells. This evidence concerns the gene CASP3 and hepatocellular carcinoma.