It is worth mentioning that although IVW analysis showed a negative association of albumin with the development of HF (OR = 0.90; 95% CI, 0.84–0.96; P = 4.22 × 10−3), MR-Egger and weighted madian showed effect values opposite to the IVW, and in addition the Egger's intercept test showed the presence of pleiotropy (P = 0.019), which violated the assumptions of MR. The gene discussed is ALB; the disease is hydrops fetalis.