Many loci associated with BFD, that are greatly distinct from those of BMI and obesity risk.S70C variant in Coiled-Coil Domain Containing 92 gene is associated with decreased visceral fat (VAT) and increased leg fat (GF-SCAT).Dynein axonemal heavy chain 10 (DNAH10), Plexin-D1 (PLXND1), R-spondin 3 (RSPO3), and lysophospholipase-like 1 (LYPLAL1) genes are high determinants of BFD.HOXA5 expression is upregulated in abdominal subcutaneous adipose tissue compared to gluteal subcutaneous adipose tissue. This evidence concerns the gene LYPLAL1 and obesity due to melanocortin 4 receptor deficiency.