Many loci associated with BFD, that are greatly distinct from those of BMI and obesity risk.S70C variant in Coiled-Coil Domain Containing 92 gene is associated with decreased visceral fat (VAT) and increased leg fat (GF-SCAT).Dynein axonemal heavy chain 10 (DNAH10), Plexin-D1 (PLXND1), R-spondin 3 (RSPO3), and lysophospholipase-like 1 (LYPLAL1) genes are high determinants of BFD.HOXA5 expression is upregulated in abdominal subcutaneous adipose tissue compared to gluteal subcutaneous adipose tissue. The gene discussed is RSPO3; the disease is Obesity.